Bufotenine and 5-MeO-DMT
The main active substance of the â€œkohobaâ€ and â€œjopoâ€ is the bufotenine. They also contain DMT and 5-MeO-DMT that also has a similar effect. The bufotenine is actually 5-OH-DMT and in structure they are very much alike with the natural nerve-mediator â€œserotonineâ€. It disintegrates very fast in the organism and therefore if it is taken in orally it doesnâ€™t have any psychometric effects.